Journal: Experimental and Therapeutic Medicine

Article Title: Role of non‑coding RNAs in UV‑induced radiation effects (Review)

doi: 10.3892/etm.2024.12550

Figure Lengend Snippet: Role of ncRNAs in UV-induced ocular diseases.

Article Snippet: It was identified miRNAs that may be sponged by downregulated circ-0011129 using the Arraystar proprietary miRNA target prediction software ( https://www.arraystar.com/reviews/cooperative-mirna-target-prediction-and-go--pathway-analysis/ ) and TargetScan ( https://www.targetscan.org/vert_80/ ), including miR-484, miR-3619-5p and miR-6732-5p, which share binding sites with photoaging-related proteins, such as COL1A1, COL3A1 and elastin.

Techniques:

Journal: Experimental and Therapeutic Medicine

Article Title: Role of non‑coding RNAs in UV‑induced radiation effects (Review)

doi: 10.3892/etm.2024.12550

Figure Lengend Snippet: Application of biological therapy targeting ncRNA in UV-induced radiation effect.

Article Snippet: It was identified miRNAs that may be sponged by downregulated circ-0011129 using the Arraystar proprietary miRNA target prediction software ( https://www.arraystar.com/reviews/cooperative-mirna-target-prediction-and-go--pathway-analysis/ ) and TargetScan ( https://www.targetscan.org/vert_80/ ), including miR-484, miR-3619-5p and miR-6732-5p, which share binding sites with photoaging-related proteins, such as COL1A1, COL3A1 and elastin.

Techniques: Expressing, Gene Expression, Irradiation, Inhibition, Transfection, Methylation, Migration

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: EEPD1 Pan-Cancer expression and genetic alteration. (A) EEPD1 Pan-cancer differential expression according to TCGA and GTEx database. (B) Mean expression of EEPD1 in multiple cancers. (C) EEPD1 expression in COAD tumor tissues and normal tissues. (D) EPD1 expression in paired COAD tumor tissues and normal tissue. (E) EEPD1 pan-cancer genetic alterations in cBioportal database.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: Association between EEPD1 and prognosis and clinic phenotypes. (A) Forest plot based on the univariate COX regression analysis of EEPD1 and OS in 33 cancers (B) Kaplan-Meier analysis of association between EEPD1 and prognosis in cancers. (C) Association between EEPD1 and tumor stage in cancers.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques:

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: Enrichment analysis of EEPD1 in colorectal cancer. (A) correlation analysis of EEPD1 in colorectal cancer. (B) GEVA of EEPD1 in colorectal cancer. (C–E) GSEA of EEPD1 based on GO, KEGG pathways and Reactome pathways.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques:

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: TME analysis of EEPD1. (A) ESTIMATE analysis of EEPD1 in caners. (B) ESTIMATE analysis of EEPD1 in CRC. (C) The correlation between the expression level of EEPD1 and TME in COAD.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: The correlation between the expression of EEPD1 and pan-cancer immune cell infiltration based on TIMER2 (Red boxes represent positive associations, green negative associations, and boxes with a cross indicate p > 0.05). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: (A)The correlation between EEPD1 expression and immune cell infiltration in colorectal cancer. (B)Circle plot of the correlation between EEPD1 expression and immune cell infiltration in colorectal cancer. cells with pearson correlation coefficient >0.15 with EEPD1 were selected for correlation circle mapping. Red represents positive correlation, green represents negative correlation, and the darker the color, the stronger the correlation. (C)The correlation between EEPD1 expression and TMB. (D) The correlation between EEPD1 expression and MSI. (E) The correlation between EEPD1 expression and tumor response to PD-L1 inhibitor. (F) Kaplan-Meier analysis of association between EEPD1 and prognosis in PD-L1 treated patients. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: The gene co-expression analysis of EEPD1 and (A) immune checkpoints, (B) chemokines, (C) chemokines receptors, (D) immune activation genes, (E) immunosuppressive genes, (F) MHC genes.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing, Activation Assay

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: The gene co-expression analysis of EEPD1 and (A) EMT down, (B) EMT up, (C) pyroptosis, (D) autophagy, (E) TGF-β1 signaling, (F) Wnt/β-catenin signaling, (G) ferroptosis, (H) MMR genes.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: The correlation between EEPD1 expression and IC50 of multiple drugs. (A–S) The EEPD1 expression is positive with IC50 of drugs. (T–Z) The EEPD1 expression is negative with IC50 of drugs.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Expressing

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: (A)The nomogram to predict OS of CRC patients. (B) Calibration plot for the nomogram. (C) ROC curve for EEPD1 and other clinical parameters. (D) ROC curve for nomogram.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques:

Journal: Heliyon

Article Title: EEPD1 is identified as a predictor of prognosis and immune microenvironment through pan-cancer analysis and related to progression of colorectal cancer

doi: 10.1016/j.heliyon.2024.e29285

Figure Lengend Snippet: EEPD1 promote cell proliferation and metastasis in CRC cells lines. (A) EEPD1 was significantly up-regulated in CRC tumor tissues According to immunohistochemistry (B) EEPD1 was significantly up-regulated in CRC tumor tissues According to RT-qPCR. (C) The expression of EEPD1 in CRC cell lines was higher than that in normal colorectal cell lines. (D)EEPD1 was knock down in HCT8 and RKO cell lines. (E, F) knockdown of EEPD1 significantly reduced the EdU-positive rate of EdU assay in RKO and HCT8 cells. (G, H) knockdown of EEPD1 significantly reduced the number of cells that cross the TRANSWELL chamber. (I, J) knockdown of EEPD1 significantly promoted the expression of P21 and P16 and showed an upward trend in the expression of Bad.

Article Snippet: EEPD1 stRNA, designed and produced by ribobio (Guangzhou, China), was used to knock down EEPD1 in CRC cells.

Techniques: Immunohistochemistry, Quantitative RT-PCR, Expressing, EdU Assay